boc-L-serine methyl ester
boc-L-serine methyl ester
CAS: 2766-43-0
Molecular Formula: C9H17NO5
boc-L-serine methyl ester - Names and Identifiers
| Name | boc-L-serine methyl ester |
| Synonyms | BOC-SER-OME Boc-Ser-OMe BOC-SERINE-OME BOC-L-SERINE METHYL ESTER boc-L-serine methyl ester N-Boc-L-serine methyl ester N-BOC-L-SERINE METHYL ESTER N-T-BOC-L-SERINE METHYL ESTER Butoxycarbonylserinemethylester methyl N-(tert-butoxycarbonyl)-L-serinate N-(TERT-BUTOXYCARBONYL)-L-SERINE METHYL ESTER N-(tert-Butoxycarbonyl)-L-serine methyl ester N-ALPHA-T-BUTOXYCARBONYL-L-SERINE METHYL ESTER |
| CAS | 2766-43-0 |
| EINECS | 690-499-7 |
| InChI | InChI=1/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-11)7(12)14-4/h6,11H,5H2,1-4H3,(H,10,13)/t6-/m0/s1 |
| InChIKey | SANNKFASHWONFD-LURJTMIESA-N |
boc-L-serine methyl ester - Physico-chemical Properties
| Molecular Formula | C9H17NO5 |
| Molar Mass | 219.24 |
| Density | 1.082g/mLat 25°C(lit.) |
| Boling Point | 354.3±32.0 °C(Predicted) |
| Specific Rotation(α) | -18 º (c=5 in methanol) |
| Flash Point | >230°F |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 1.94E-06mmHg at 25°C |
| Appearance | Pale yellow liquid |
| Color | Colorless to yellow |
| BRN | 3545389 |
| pKa | 10.70±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.452(lit.) |
| MDL | MFCD00191869 |
boc-L-serine methyl ester - Risk and Safety
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29241990 |
boc-L-serine methyl ester - Reference Information
| application | Boc-L-serine methyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
| preparation | 3.1kgL-serine is dissolved in 30L methanol, 2.2L of thionyl chloride is added at room temperature, stirring for 2h and refluxing for 8h after adding, the reaction liquid is concentrated and spun-dried, the concentrated liquid is dissolved in 30L of dichloromethane, 9.2L of triethylamine and 7.25kg of dicarbonate is added, cooled in ice water, the temperature is not more than 20 ℃, and the addition is completed, stir at room temperature for 8 hours, wash the reaction liquid with 1N sodium bisulfate solution, 5% sodium bicarbonate solution, 10% citric acid and saturated salt water, dry the organic phase with anhydrous sodium sulfate, and remove the solvent under reduced pressure to obtain compound I 6.38kg with a yield of 94%. |
Last Update：2024-04-09 21:54:55
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